Organic chemistry
o2h discovery is a highly reputed service provider of mg/g scale discovery chemistry. We have partnered with a range of well known pharmaceutical and biotechnology companies from Europe, USA and Japan.
The specialised team at o2h discovery has a broad array of experience in preparing small molecule NCEs with the requisite high quality specifications. It is proficient in utilising perse methodologies, including the synthesis of singles, multi-step, small arrays as well as focused libraries. Our scientific team is also experienced in parallel construction of focused libraries for use in hit-to-lead and lead optimisation projects.
The delivery of all our compounds is accompanied with complete characterisation data including, but not limited to, high-field NMR, mass and purity by LC-MS/HPLC/GC.
Access to databases such as SciFinder and Beilstein provides the team with all the necessary current information to modify and develop new synthetic routes.
o2h discovery has experience of a wide range of chemistry including:
- Chiral chemistry
- Aliphatic, aromatic and heterocyclic chemistry
- Carbohydrate chemistry
- Peptide chemistry
- Steroid chemistry
- Nucleoside chemistry
- Combinatorial chemistry
- Natural product chemistry
- Fragment libraries
- Metabolite/impurity/reference synthesis
- Microwave chemistry
Medicinal chemistry
o2h Discovery, a leading CRO specializing in medicinal chemistry services, delivers high-quality drug discovery solutions through our integrated, multi-modality capabilities and state-of-the-art facilities in Cambridge, UK, and Ahmedabad, India. We work at the critical interface of chemistry and biology, partnering with global biotech and pharma companies to accelerate the development of innovative therapies.
Our medicinal chemistry expertise spans the full spectrum of small molecule design and synthesis, from traditional heterocyclic and carbocyclic chemistry (including carbohydrates and steroids) to complex modern modalities. These include PROTACs, molecular glues, peptides, and oligonucleotides, where our integrated approach helps advance even the most challenging drug discovery programs.
By combining deep scientific knowledge with flexible collaboration models, o2h Discovery enables partners to efficiently scale their research, reduce timelines, and bring breakthrough medicines closer to patients.
Some of the key expertise includes:
- Target Validation (with integrated biology support)
- Hit Identification & Lead Generation
- Lead Validation
- Lead Optimisation
These services can be accessed independently or as part of an integrated drug discovery platform, providing flexibility for both early-stage biotech ventures and established pharma R&D programs. Read more about our Medicinal Chemistry Services here.
Computational chemistry
Computational chemists at o2h discovery work at providing stand-alone services to our clients with in silico based screening projects as well as supporting medicinal chemistry projects. Computational chemistry expertise includes molecular modelling, virtual screening and drug designing.
Virtual screening services include target identification, in silico drug-likeness, screening of client/commercial databases to identify focused lead/hit compounds and docking studies to prioritise hits for in vitro studies.
Drug designing to support hit generation and lead optimisation are applied to augment medicinal chemistry design efforts and help guide structural modifications to enhance potency, selectivity and drug-like characteristics. Close cooperation between our molecular modellers and medicinal chemists plays a vital role in this process.
Apart from these, we also support designing target-focused libraries, target modelling, molecular dynamic simulations and developing highly predictive 3D-QSAR models based on target and therapeutic areas.
Chemical biology
o2h discovery expanded its capability to support several chemical biology projects to deliver bespoke, high quality tools to positively impact target validation and mechanistic understanding.
This includes cutting edge research to prepare key diverse intermediates alongside developing optimised construction methods to prepare these complex molecules in the most efficient manner. The involvement of our analytical group plays an essential role to ensure these tools are isolated in the most appropriate way to meet the required compound specifications and deliver high quality biological data.
Antibody drug conjugate
Bespoke Intermediates for ADCs
Building on our expertise to support small molecules drug discovery programs, we have now extended our service offering to projects in ADC space as outlined below.
Our service offering includes the synthesis, development and scale-up of bespoke Linker, Linker-Reagent, Reagents, Peptide scaffolds, and associated intermediates to meet our collaborator's specifications for their R&D needs.