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Press Release – PhoreMost and o2h discovery collaborate to progress first-in-class drug discovery programs

PhoreMost, the UK-based biopharmaceutical company dedicated to drugging ‘undruggable’ disease targets, today announced it has entered into a collaboration with o2h discovery (o2h), an Anglo-Indian medicinal chemistry company that has in-house capability to take drug discovery programmes to the IND filing stage.

PhoreMost has built a pipeline of novel targets and early drug discovery programmes using its next-generation “SITESEEKER®” phenotypic screening platform. The collaboration will see o2h deploy its expertise in medicinal chemistry to help progress PhoreMost’s portfolio rapidly through the hit-to-lead and lead-optimisation stages of drug discovery.

Dr Chris Torrance CEO of PhoreMost, said: “Since its inception, PhoreMost’s model has been to forge a new approach to drug discovery, working collaboratively with partners in order to progress new medicines. The alliance with o2h truly reflects this, and represents an important step in our mission to bring a greater diversity of therapies to patients, more quickly and at affordable prices.”

 We have been impressed by the ability of PhoreMost’s SITESEEKER platform to systematically identify first-in-class drug targets in areas of high unmet need, and are excited to be applying our highly complementary capabilities to develop these potentially high value programs,” said Sunil Shah, CEO of o2h discovery: “Our shared vision of working collaboratively is also a testament to the strength of the Cambridge UK Biotech cluster for discovery and progressing the next generation of therapeutics.”

PhoreMost recently announced the completion of an £11m ($15m) Series-A investment round. The investment will be used to expand operations on the Babraham Research Campus and progress several novel drug targets from its next-generation “SITESEEKER” phenotypic screening platform into first-in-class drug discovery programmes.

Press Link – Phoremost and o2h Discovery

Press Release – Curza and o2h discovery announce a multi-FTE chemistry collaboration against gram negative

Curza Global, LLC and O2H DISCOVERY (O2H) are pleased to announce a multi FTE chemistry collaboration to support Curza as it drives its lead program targeting dram negative through lead optimization and towards the clinic.

Curza’s lead program is a new class of broad spectrum antibiotics, focused on ESKAPE pathogens and drug-resistant Gram-negative bacteria. Inspired by a natural product, this class targets an unexploited binding site of the bacterial ribosome.

o2h is pleased to collaborate with industry leader, Curza, to tackle the rapid and global spread of antimicrobial resistance. Working through different pathways Curza hopes to design effective new drugs to tackle gram-negative infections The approach Curza has taken is unique and management is very focused to ensure their drug makes its way to patients quickly.

Sunil Shah, CEO of O2h “The rapid and global spread of antimicrobial-resistant organisms in recent years has been unprecedented. Although resistant Gram-positive infections have been concerning to clinicians, the increasing incidence of antibiotic-resistant Gram-negative infections have become the most pressing issue in bacterial resistance.”

Ryan Davies, CEO of Curza “We are very happy to be working with O2h on this program. We wanted to make fast progress with this project and O2h’s focus on execution speed is a key reason why we selected them to work on our highest priority project.

About O2h: o2h seeds new ideas in science, technology and social enterprise. We work across boundaries and take a collaborative and shared approach to innovation, and therefore we co-invest, co-create and co-execute to bring these ideas to life. o2h discovery is an integrated chemistry and biology services capability for collaborative research and o2h ventures supports early stage life science assets through seed investment. o2h is organized into 6 verticals including discovery, ventures, technology, therapeutics, co-work and community, and is co-located in Ahmedabad, India and in Cambridge UK. Please see www.o2h.com for more details.

About Curza: Curza is a Utah-based drug development company focused on developing novel therapeutics to control antibiotic resistant bacteria. With original technology licensed from the University of Utah, Curza is in the early stages of developing two novel classes of antibiotics. Headquartered in Salt Lake City, UT with offices in Cambridge, MA, Curza is privately held and backed by Clarke Capital Partners and other private investors. Please visit www.curza.com for more information.

Chemistry in the Cloud™ – The World’s First App To Project Manage Drug Discovery

The quest to positively benefit the lives of patients in the world of drug discovery means finding novel therapeutics for unmet medical needs. The biotech and pharma companies have been increasingly resorting to external innovation to supplement their pipeline of ideas and turbocharge their research-based businesses with enterprising partners with complementary ideas, capabilities and services. It is therefore hardly surprising that the top medicinal chemists working in both large and small companies have multiple partners across different continents and time-zones.

To deliver these iterative discovery projects often entails detailed co-ordination of inter-related activities and extensive multi-tasking. Project management is the hub that allows these complex matrices of networks to communicate and for the project to successfully advance. In today’s fast paced and technologically advanced digital world, providing the project manager the right tools to make informed decisions is key to successful delivery.

o2h Discovery’s innovative app Chemistry in the Cloud TM builds upon the latest advances in secure cloud-based mobile technology and integrates project management of external drug discovery programs. The app enables communication between the various scientific stakeholders essential to successful project advancement leading to faster decision making. It negates the onerous tasks of weeding out critical information that is required to take a complex decision by extracting the information from large data intensive reports and databases. These crucial decision points are now just a ‘tap/swipe-of-the-finger’ in the Chemistry in the CloudTM app so that they can speedily execute tasks anytime, anywhere. The communication covering a gamut of research activities in relation to process of research now truly happens in 24/7 real-time.

o2h announced a worldwide launch and first live demonstration of our revolutionary project management app – Chemistry in the Cloud TM on 10th September 2017 at the 19th RSC/SCI Cambridge medicinal chemistry conference to some of world’s top scientists. The app’s full suite of project management tools is available exclusively to live project collaborators and a lighter version is open for researchers looking for a quote for the synthesis of small molecules.

https://www.linkedin.com/in/sunil-shah-4bb225/detail/recent-activity/shares/
Nilesh Dagia (nilesh@o2h.com) is the COO @ o2h Discovery

o2h to attend these upcoming conferences

o2h Discovery is pleased to announce a 10 FTE Synthetic Chemistry collaboration with Heptares

o2h Discovery is pleased to announce a 10 FTE Synthetic Chemistry collaboration with Heptares. Giles Brown, Director of Medicinal Chemistry: “Heptares is pleased to expand its discovery chemistry collaboration with o2h. The group has demonstrated good value for Heptares with a focus on fast turn-around, transparent communications and speed of delivery.” Sunil Shah, CEO: “We are very happy to support this incredible group of scientists at Heptares.

Orfan Biotech, a company dedicated to developing small molecules for the treatment of Primary Hyperoxaluria

o2h Update: “Orfan Biotech, a company dedicated to developing small molecules for the treatment of Primary Hyperoxaluria. Orfan has a collaboration with o2h involving financial and medicinal chemistry support. Hans Maag, Med Chemist, Orfan, “We are very thankful to the research partnership with o2h which is allowing Orfan to efficiently and effectively drive our Medicinal Chemistry programs. This partnership demonstrates the power of bringing together insights generated by the Orfan founders with state-of-the art drug discovery and chemistry expertise built in collaboration with the o2h”

o2h volunteers visit “Jeevan Dhara” – Old age home, Ahmedabad, India.

As a part of our community service seven of the o2h team went to “Jeevan Dhara” – an Old People’s home based in Ahmedabad last Saturday.  The old people’s home does not take a fee but expects the residents to contribute to the running of the home.

The days was highly enjoyable and fulfilling for both the o2h volunteers and the elderly; “happy and delighted” was the most commonly used phrase in the day!

The o2h team reached “Jeevan Dhara Old Age Home” at around 10:30am. The visit started with visiting the Ashram with the staff. After the orientation and induction the team visited to the eye care hospital, rooms donated by people, religious library, etc.

The team then spent time with the elderly chatting and gossiping, many remember the o2h team from the earlier visits and were happy to see the familiar faces. Learning about the life stories, children and grandchildren was very enjoyable. There were also many valuable life lessons which the team appreciated. The eldely residents really enjoyed taking pictures with the team members, seemed to be a favourite hobby for many of them. o2h volunteers served food in the canteen at lunch-time before it was time to wave goodbye with a future visit date agreed.

Experience of Volunteers…

“It was a nice experience. The facilities provided were very good. A much needed service, one lady was awaiting admission as she was sent out of her home by her children and was & pleading for shelter.”

“It was awesome experience. When we met them they were feeling very happy & ultimately due to which we also felt good & happy. The activities which the Oldage home is conducting & the way they are managing is really appreciable. A great feeling came from my heart when we served them food, they were excited to as such what is in lunch. I served them fulvadi for which some where happy to have & some confused between whether to eat or not because of the problem in their teeth. There are lots of feelings but those can only be felt & not expressed in words.”

“It was indeed a very nice experience to visit old age home. It feels very bad that at the age of above 60 they have to live without their children when they needed them the most. We should not forget that at our childhood they have sacrificed a lot to see their child in a good position in future. We shared some quality time with these old age people and they have shared their personal experiences which can be beneficial to our life.”

“It was really a good experience of my life. I was very emotional that time when we met the lady over there & she shared her feelings with us. It is very true that our generation needs to change the things. It was best moment in my life. We will also start to campaign with friends to meet this type of people and listen to their voice and feelings.”

“I had a great time there, sitting with them hearing their life stories with amazing experience. They all welcomed us with love. I learnt many things. Thank you o2h for organizing such community services. It was a heart touching experience…!”

“It was a nice experience. We talked with them & realized they were missing their home, their children, grandchildren badly.”