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A passion for

innovation

We are constantly innovating our people, project management and technology models leading to outstanding results for our collaborators. The world’s first app based technology platform Chemistry in the CloudTM enables us to work together to make faster decisions. Our deep understanding that an early and intensive evaluation of target molecules based on real insight into the science will lead to faster downstream execution. The result is a higher throughput of successful drug-like compounds.

Chemistry

A passion for

innovation

We are constantly innovating our people, project management and technology models leading to outstanding results for our collaborators. The world’s first app based technology platform Chemistry in the CloudTM enables us to work together to make faster decisions. Our deep understanding that an early and intensive evaluation of target molecules based on real insight into the science will lead to faster downstream execution. The result is a higher throughput of successful drug-like compounds.

Organic chemistry

o2h discovery is a highly reputed service provider of mg/g scale discovery chemistry. We have partnered with a range of well known pharmaceutical and biotechnology companies from Europe, USA and Japan.

The specialised team at o2h discovery has a broad array of experience in preparing small molecule NCEs with the requisite high quality specifications. It is proficient in utilising perse methodologies, including the synthesis of singles, multi-step, small arrays as well as focused libraries. Our scientific team is also experienced in parallel construction of focused libraries for use in hit-to-lead and lead optimisation projects.

The delivery of all our compounds is accompanied with complete characterisation data including, but not limited to, high-field NMR, mass and purity by LC-MS/HPLC/GC.

Access to databases such as SciFinder and Beilstein provides the team with all the necessary current information to modify and develop new synthetic routes.

o2h discovery shas experience of a wide range of chemistry including:

  • Chiral chemistry
  • Aliphatic, aromatic and heterocyclic chemistry
  • Carbohydrate chemistry
  • Peptide chemistry
  • Steroid chemistry
  • Nucleoside chemistry
  • Combinatorial chemistry
  • Natural product chemistry
  • Fragment libraries
  • Metabolite/impurity/reference synthesis
  • Microwave chemistry

Medicinal chemistry

Medicinal chemistry expertise available at o2h discovery includes hit identification, hit-to-lead optimisation, lead generation, and lead optimisation. All of these can be accessed as stand-alones or as a part of an integrated drug discovery project.

Hit identification/lead generation projects have involved ligand design for customer-defined targets, synthesis of homologous or diverse series of compounds, design and generation of structurally related compounds, combinatorial synthesis of general as well as focused libraries and search for surrogates of core chemical scaffolds.

Hit-to-lead projects typically involve confirmation of a genuine structure-activity relationship (SAR) and reducing structural/pharmacological liabilities. o2h discovery has the capability to synthesise small focused arrays of compounds in sufficient quantities to allow clients to rapidly screen these compounds for ADME and in vitro biological activity (primary as well as secondary screenings).

For projects advancing to lead optimisation phase, chemists at o2h discovery work intensively with their biology counterparts to produce compounds which closely match the desired target product profile. Typically, this involves a thorough search of prior art and assuring patentability, generation of back-up series and leading the compounds to in vivo proof-of-concept. Our biologists can assist in generating in vivo experimental models recapitulating a particular human pathological condition, designing and efficiently executing PK/PD, toxicology and other relevant pharmacological studies to advance these compounds further.

Computational chemistry

Computational chemists at o2h discovery work at providing stand-alone services to our clients with in silico based screening projects as well as supporting medicinal chemistry projects. Computational chemistry expertise includes molecular modelling, virtual screening and drug designing.

Virtual screening services include target identification, in silico drug-likeness, screening of client/commercial databases to identify focused lead/hit compounds and docking studies to prioritise hits for in vitro studies.

Drug designing to support hit generation and lead optimisation are applied to augment medicinal chemistry design efforts and help guide structural modifications to enhance potency, selectivity and drug-like characteristics. Close cooperation between our molecular modellers and medicinal chemists plays a vital role in this process.

Apart from these, we also support designing target-focused libraries, target modelling, molecular dynamic simulations and developing highly predictive 3D-QSAR models based on target and therapeutic areas.

Chemical biology

o2h discovery expanded its capability to support several chemical biology projects to deliver bespoke, high quality tools to positively impact target validation and mechanistic understanding.

This includes cutting edge research to prepare key diverse intermediates alongside developing optimised construction methods to prepare these complex molecules in the most efficient manner. The involvement of our analytical group plays an essential role to ensure these tools are isolated in the most appropriate way to meet the required compound specifications and deliver high quality biological data.

Antibody drug conjugate

adc-dicvory1

Bespoke Intermediates for ADCs 

Building on our expertise to support small molecules drug discovery programs, we have now extended our service offering to projects in ADC space as outlined below.

Our service offering includes the synthesis, development and scale-up of bespoke Linker, Linker-Reagent, Reagents, Peptide scaffolds, and associated intermediates to meet our collaborator's specifications for their R&D needs.

Biology

A passion for

innovation

We are constantly innovating our people, project management and technology models leading to outstanding results for our collaborators. The world’s first app based technology platform Chemistry in the cloudTM enables us to work together to make faster decisions. Our deep understanding that an early and intensive evaluation of target molecules based on real insight into the science will lead to faster downstream execution. The result is a higher throughput of successful drug-like compounds.

ADME screening services

In vitro facilities at o2h discovery provide ADME (absorption, distribution, metabolism, excretion) to provide faster and improved decision making points for our chemistry clients or standalone offering to support drug discovery programs.

We offer cost-efficient standardized and customized assays as per the client’s requirement for ADME parameters. Our ADME capabilities include:

ADME Assays

  • Physicochemical screening
    • Aqueous solubility (Thermodynamic & Kinetic)
    • Log P
    • Log D
  • Drug Metabolism
    • Microsomal Stability
    • Plasma Stability
    • Hepatocyte Stability
  • Protein Binding
    • Plasma Protein Binding
  • Permeability
    • PAMPA
  • Drug-Drug interaction
    • CYP inhibition assays (Fluorescent and LCMS/MS)

In vitro assays

In vitro facilities at o2h discovery have been developed to provide faster decision-making points for our chemistry clients.

We have doubled both our capacity as well as capability to include a range of pharmacology services to evaluate activity and/or potential liability of compounds. Our purpose-built labs include industry standard formats of fluorescence, luminescence and absorbance to help develop and optimise biochemical and/or cellular assays in a range of therapeutic areas.

o2h discovery offers:

ADME Assays
Solubility (thermodynamic, kinetic), Log P/Log D studies, permeability (PAMPA), CYP inhibition (fluorescence, LCMS/MS based), microsomal stability, plasma stability, hepatocyte stability, plasma protein binding.

Target-based Assays
Enzymatic/kinase assays, binding assays, GPCR assays

Cell-based Assays
ELISA, proliferation/cytotoxicity, phosphorylation status, cytokine production assays using hPBMCs, signal transduction assays.

In vivo studies

in-vivo-studies-1

o2h discovery has an in-depth expertise in performing standard bioavailability/tissue-distribution PK studies, acute/chronic toxicology studies as well as pathophysiologically relevant experimental models for multiple therapeutic indications.

The macroscopic observations can be corroborated with a range of different techniques including but not limited to histopathological analysis, estimation of haematological and/or biochemical parameters etc. Currently, the in-vivo experiments are performed only with rodents (e.g, mice, rats). Our in-vivo models are available on a fee-for-service basis as well as a part of an integrated biology project. We also have the capability to customise these models as per client requirement. In-vivo studies are done in conjunction with CROs with whom o2h has a preferred relationship for the past several years.

Examples of in vivo models include

  • Collagen-induced arthritis
  • Adjuvant-induced arthritis
  • DSS-induced colitis
  • TNBS-induced colitis
  • PMA-induced psoriasis/atopic dermatitis
  • IMQ-induced psoriasis/atopic dermatitis
  • Cytokine release assay
  • Single dose acute toxicity
  • Repeat dose toxicity study
  • Oral bioavailability study

Integrated drug discovery

The ultimate metric to measure the success of Integrated Drug Discovery (IDD) project is the capacity to create intellectual property and value to our customers (e.g., identification of a lead compound demonstrating low nM activity under in vitro conditions and exhibiting statistically significant in vivo efficacy in a pathophysiologically-relevant disease model).

Successful IDD projects rely on efficient integration of various disciplines, medicinal chemistry experience, operational excellence and a pragmatic approach. o2h discovery has taken a modular approach while establishing its IDD services to offer our clients maximum flexibility in their outsourcing decision.

Each of the varied module of the drug discovery process is available as a unique point of entry individually as a subset of services or as the traditional drug discovery pathway from hit identification through to lead generation and beyond. Our expertise includes – medicinal chemistry, hit identification, lead generation/optimisation, computational chemistry, in-vitro enzymatic and cell-based screening, DMPK and in-vivo models in multiple therapeutic areas. o2h discovery doesn’t have an animal facility, the in-life phase for PK studies as well as in-vivo efficacy studies are done with CROs with whom we have a preferred relationship for the past several years.

o2h discovery has strategic ties with several CROs in India and can help clients advance their projects to an IND application stage through chemical process scale-up and development (both GMP and non-GMP), bioanalytical studies, formulation approaches, safety-pharmacology and toxicology studies, clinical trial supplies, and medical writing. To know more about this, please write to us at info@o2h.com

Delivery

A passion for

innovation

We are constantly innovating our people, project management and technology models leading to outstanding results for our collaborators. The world’s first app based technology platform Chemistry in the CloudTM enables us to work together to make faster decisions. Our deep understanding that an early and intensive evaluation of target molecules based on real insight into the science will lead to faster downstream execution. The result is a higher throughput of successful drug-like compounds.

High speed delivery

high-speed-delivery-bannerThe delivery model has been designed for speed around effective project management, processes/equipment and people.

The highly secure laboratory modules come fully equipped with well-established operational processes combined with a highly skilled and dedicated project teams with experience of cross-border collaborations, ready to undertake cost-effective and 24-6 high speed drug discovery.

The effectiveness of the operations in India is boosted by the UK project office (Cambridge) which provides logistical, communications and objective project management support.

o2h discovery understands that early and intensive evaluation of the molecules based on thorough communications and rapid decision-making will lead to a high throughput of successful drug-like compounds.

Full lab service units

Chemistry at o2h discovery is performed at its custom-built, state-of-the art greenfield campus with 6 lab units with a capacity for 120+ employees.

Each lab unit is an IP/IT secure, spacious module with 8 fume-hoods and an accompanying write-up area. The modularity of this design enables us to provide a comfortable work-area for our chemists and also customise client-experience, while assuring high level of security. All lab units are accessible via key-card access only and benefit from an integrated engineering and central services support.

Our campus incorporates the highest standards of safe operations and the latest in both proven and experimental environmental thinking applicable to discovery research activity in the extreme Indian climatic conditions. LUX, motion controllers and low energy natural coolers are some of these features. In the lab units, fume-hoods are VAV controlled with fire-tracer extinguishers.

Project management

Discovery speed is at the very heart of all project management at o2h discovery. Effective project management and communication is an integral element of ensuring fruitful interactions and positive outcome for the project. o2h discovery has perfected, over a number of years, simple yet clear templates which enable the systematic day-to-day reporting and measurement of scientific progress in the most effective manner.

Performance and productivity metrics are the foundation of the o2h discovery operational model. The metrics are updated on a weekly basis as per the o2h discovery's internal project management systems. Data is represented in a graphical form, where possible, and shared internally as well as with the client. o2h discovery has innovated a comprehensive system of 20 “dashboard metrics” to improve productivity & delivery performance. These dashboard metrics enable us to analyse and optimise our performance through a continuous cycle of improvement.

o2h discovery monitors a range of indicators on a compound, per FTE, project, month and quarterly level. For example, the metrics in synthesis include the number of trial reactions, successful reactions, purifications, number of steps, final compounds, average time per reaction or step, number of deadline changes per compound, delays per compound, classification of the reasons for the delay in delivery of a compound, and even the timeliness of the status reporting and despatch.

Communication

Communications with clients range from direct communication - the most obvious and rapid means of solving issues-to secure space on our intranet site for depositing documents and data arising during the projects.

During our initial interaction at the start of the project, we identify the optimal communication protocol with the client and follow this diligently throughout the project.

Other channels of project management and communication include:

Project status reports

One page tabulated summary outlining progress of the project, highlighting any potential issues and tracking progress against deadline.

o2h discovery Dashboard performance metrics

o2h discovery also records a wide range of performance data. This is uploaded to the secure website on a bi-weekly cycle.

Project feedback form

At the end of every phase of the project o2h discovery asks its clients to fill in a feedback form, which provides o2h discovery with objective information that is useful in improving service. This data is collated, analysed and then distributed to all senior professionals in o2h discovery.

Process mapping

o2h discovery has spent considerable time to map and document all processes within the organisation to ensure that each individual, from business development to group-leaders and bench chemists, knows exactly at what step their input will be required.

Though initially an intensive process, this defined process management means there is a clear path for communication as well as trouble-shooting when needed.

o2h discovery also continuously monitors and updates its processes to keep them relevant and optimised. This process is a part of the feedback loop from both in-house scientists and our clients to ensure that client priorities are met and correct deliverables are set at each point of the project.

Starting materials & supply chain

Prompt delivery of starting materials is crucial to fast start of a project and the key to our drug discovery and delivery speed.

Our dedicated team of personnel includes purchasing officers, store/stock managers as well as in-house customs liaising officer. Over the course of past several years, we have identified a list of suppliers, both locally and internationally, with account managers in larger suppliers dedicated to our orders. We evaluate delivery metrics and work together with our suppliers to continuously improve starting material delivery.

The supply process is mapped out, with expected delivery times from various suppliers. This metric is monitored monthly and we actively work with our suppliers to improve delivery lead times. o2h discovery also maintains an inventory of most commonly used chemicals and reagents in-house to further aid delivery speeds of drug discovery projects.

With over a decade of experience working in this industry, o2h discovery has understood the impact of supply chain performance on overall synthesis performance and has game changing advantages vs. other competitors in India.

Structural advantages

  • o2h discovery being an Export Oriented Unit (EOU) we are able to reduce (compared to an SEZ) the turn-around time for import chemicals due to elimination of two entire layers of customs processing/clearance.
    • Layer 1 – pre-clearance of import shipments
      • In an SEZ we have to file the Bill of Entry (BOE) only after transhipment from Mumbai to Ahmedabad while at EOU we can start the process of custom clearance of import shipments in advance of it landing in Mumbai airport via our custom officer where we can save 2-3 days
    • Layer 2 – no clearance at the gate
      • In the SEZ a custom clearance officer sits at the gate of the campus and is required to approve each shipment before it reaches the scientists. This custom clearance step may lead to delays of up to 1-2 day(s) as that officer receives shipment from a # of companies simultaneously which can result in a lengthy queue. This issue is compounded if the officer is unavailable (e.g., due to his illness, has to go on other government business, his own discretion). No such process exists for EOU.

    We save 7 days on a shipment from Combiblocks, 5 days on a shipment from ARK Pharma and 7 days on a shipment from Apollo Scientific.

 

Process/Internal advantages

  • Reduced hierarchy leading to faster approval (same day, in fact in matter of minutes) and same day processing of purchase orders for chemicals.
    • A dedicated 2nd shifter working in Purchasing Team specifically for import chemical ordering – resulting in chemical ordering and tracking over an extended portion of day/night matching the time-zone of import suppliers.
  • The key purchase processes have been mapped to understand and optimize the chemicals procurement process.
  • Efficient utilization of extensive vendor base locally (in Gujarat) and domestically (in India)
    • 70% of our chemicals are procured locally – turn-around time 1-2 days from placing the PO.
    • Strategic relationship with major domestic vendors (Sigma, Alfa Aesar and TCI India – each has a bonded ware-house i.e., option to procure chemicals in duty-paid/duty-free mode).
      • 17% of our chemicals are procured domestically – turn-around time 2-3 days (duty-paid orders) or 7 days (duty-free orders).
    • Tactical relationship with Blue-Dart (courier agency) for minimizing transit time of shipments.
  • Wider network of suppliers for import chemicals - across USA (e.g., Combiblocks), UK (e.g., Apollo Scientific), China (e.g., ARK Pharma), Germany (e.g. Enamine).
    • At o2h discovery we have a non-hierarchical set-up where we process the order same day to get faster delivery.
    • 13% of our chemicals are procured internationally. Turn-around time 8-9 days (duty-paid orders) or 10 days (duty-free orders).
    • Tactical relationship with courier agencies (e.g., DHL, FedEx) for minimizing transit time of shipments as well as facilitating faster clearance process.
    • Dedicated custom house agent (CHA) in Mumbai as well as in Ahmedabad for assisting with custom clearance of shipments (e.g., responding to any custom officer queries).
  • Supply chain team that is incentivized based on overall project performance inclusive of supply chain measures.

Facilities & equipment

facilities-and-equipment-newo2h discovery’s 2,000 m2 greenfield campus is an Export Oriented Unit (EOU), which is government sponsored duty free environment to encourage export and industrialisation.

Our campus benefits from pre-clearance of import shipments, no custom clearance at gate and secure buildings with access control points.

Activities of the lab units are supported by the surrounding research campus, an all glass conference area and a social entrepreneurship zone supporting work in the local community. To create an environment where scientists can be mentally refreshed, the building has elegantly designed courtyards.

IP/IT safety

o2h discovery understands the responsibility it has to protect the IP of its clients during a formative stage of the discovery process.

The o2h discovery IP security model is designed to protect the IP of the clients during the project lifecycle and beyond. We have prepared a white paper to detail the IP security measures that o2h discovery has in place to protect the IP of its clients and to provide the necessary level of confidence for the client to enter into or extend an existing collaboration with o2h discovery.

In this white paper all procedures are examined from the set-up, communications, technological, legal, operational, infrastructure, people, culture and organisational angles. We have thus taken a lifecycle perspective to the use and protection of IP during all phases of a project. The o2h discovery process or policy is rated in relation to the likely risk level and therefore its importance. The responsibility for ensuring the execution of the policy or process has been clearly identified.

Some of the key features include:

  • CDA signed with all employees (if required CDAs can be executed directly between clients and project teams at o2h discovery)
  • Upfront patent assignment on MSAs
  • Mandatory checks to ensure adherence to IP Process

Analytics

o2h discovery places particular emphasis on enhancing the trouble-shooting time and efficiency of its scientists and hence we have a dedicated analytical suit with a ratio of 1 analytical scientist to every 4 chemists.

This suit is equipped with a multi-probe Bruker 400 Mhz NMR, LCMS, several HPLCs/mass directed PREP HPLCs, detectors, GCs, microwaves and other scientific equipment to enable high throughput purification and analysis, and provides 24/7 operational support. The performance of this critical facility is monitored weekly and held to a strict internal benchmark.

This benchmarking takes into account not only our internal usage metrics, but also embraces the standards of leading organizations in our industry. We also allocate budget to quickly add capacity if the projects demand. Simultaneously, we maintain service agreements with the suppliers both in the UK and India for timely delivery and maintenance of each piece of equipment.

360 degree support

360-degree-support1Success of drug discovery projects depends on timely trouble-shooting and finding pragmatic solutions to potential issues.

Scientists at o2h discovery are supported by a 360° support system which aims at maximising their time to focus on their projects. These support systems include second-shift scientists, 24/7 analytical labs and access to online scientific databases.

Each project team at o2h discovery is allocated support staff consisting of lab technicians, second-shift chemists and analytical chemist. The scientists are also supported by the purchasing team, UK office and project managers.

A vital part of 360° support is also the continuous technical skills update and training in new techniques of our employees with regular scientific training programs and expert research seminars.

Skills advantage

o2h discovery has focused on building an environment of learning and empowerment, where each scientist is encouraged to take full responsibility of their work and pro-actively seek resources and support they require for optimal delivery.

Continuous improvement of a scientist’s skills and keeping abreast of latest techniques is essential for drug discovery success. Regular seminars, held twice monthly, are scheduled in important areas of science, leadership and communications by in-house experts and speakers invited on suggestion from scientists.

This culture has resulted in very low attrition rates of our scientists, which benefit our clients by enhancing IP safety and retention of skills within the company. o2h discovery also continuously monitors and updates its processes to keep them relevant and optimised. This process is a part of the feedback loop from both in-house scientists and our clients to ensure that client priorities are met and correct deliverables are set at each point of the project.

Entrepreneurial scientists

o2h discovery considers each of its scientists as entrepreneurs and aims to provide them with an environment that encourages continuous learning and self-development.

We value scientists that take control of their projects and proactively deliver to the best of their abilities. To further encourage leadership in their roles and keeping in mind the focus of being the best service company in the world, 12.5% of each scientist’s compensation is linked to client feedback. We diligently collect project priorities at the start of the project, which are communicated to the respective scientists and team leaders to help them deliver to these priorities.

Proactive problem-solving via direct and frequent communication with the client is supported by our in-house training programs in communication and English speaking, along with sensitization to cross-cultural issue, which might affect project delivery. Our scientific liaison officer based in Cambridge, with experience both in India and UK, further supports our scientist in this regard.

Collaborators

A passion for

innovation

We are constantly innovating our people, project management and technology models leading to outstanding results for our collaborators. The world’s first app based technology platform AI Chemistry in the CloudTM enables us to work together to make faster decisions. Our deep understanding that an early and intensive evaluation of target molecules based on real insight into the science will lead to faster downstream execution. The result is a higher throughput of successful drug-like compounds.

Project initiation

A keen understanding of collaborators priorities and a fast start are the two essential features for discovery projects at o2h discovery.

Project initiation process starts with business development, where our managers ensure that scientific and other project priorities are identified with each collaborators and communicated to the project leader. At the first collaborators meeting with the team, a questionnaire is populated with details of compound priorities, delivery scheduling, communication format and delivery, access to dedicated intranet project site etc. These details form the crux of all collaborators interactions at o2h discovery.

All collaborators initiation data is coupled with internal processes involving project team allocation and emailing of the project team introduction form and are together a part of the fast start metrics. This metric is collected and evaluated monthly at o2h discovery to monitor and ensure right start of each project.

Feedback

Continuous improvement is the central ethos of all work carried out at o2h discovery and this has been a valuable part of our growth story, where client feedback has played a central role. Client feedback is also used internally as a component to employee bonus.

A detailed client feedback form is sent at the end of each project or at the end of the year (for longer projects). Responses from this feedback form are analysed against project priorities set in the project initiation form and this analysis is discussed with the client to ensure client satisfaction. For longer term projects, this is also an opportunity for all stake-holders to re-visit their priorities and ensure that effective research goals are set/re-defined.

Our communications are tailored to highlight any potential challenges during the project and to take immediate corrective action. In cases where any problems are identified in the client feedback form, the analysis performed with the team ensures that we learn from this experience, take corrective action and avoid miss-steps in future projects. A client feedback form is treated as a part of the operational process rather than a stand-alone exercise to continuously learn, improve and grow the strengths of our employees and o2h discovery.

Testimonial

o2h discovery has grown its business from collaborator references, some of which we would like to share with you. Please get in touch if you would like to contact some of our collaborators to explore working with us on your drug discovery projects.

o2h discovery have supported's drug discovery activities for the past 10 years! As part of our ongoing joint collaborative agreement, …. was pleased to award o2h discovery with their first milestone payment.

UK Biotech

The …..-o2h discovery collaboration is progressing in a good direction, with recent advances in one of our series pushing potencies 100-fold since initiated chemistry in August 2015. We are looking forward to further develop the collaboration between our teams!

Swedish Biotech

o2h discovery have been instrumental in spinning out …. from both investment to discovery activities which are essential for virtual biotech companies. Their business model of investment and risk sharing is innovative and they have been be very helpful and responsive to our needs as a small start-up company

UK Biotech

o2h discovery have been quick to respond and support our discovery efforts with whatever is required to support the company. They are flexible and skills span beyond synthesis. A highly valued collaborator.

Israeli Biotech

Happy to be working with o2h discovery, now that I'm sailing under a new flag. Thanks to the energy and effort of the team at o2h discovery, …… is moving very rapidly to build an exciting new technology. Many thanks to all!

US Biotech

o2h discovery supported our discovery efforts in a highly professional way and delivered quickly to a high purity and were also very good value for money!

Israeli Biotech