A passion for

innovation

We are constantly innovating our people, project management and technology models leading to outstanding results for our collaborators. The world’s first app based technology platform Chemistry in the cloudTM enables us to work together to make faster decisions. Our deep understanding that an early and intensive evaluation of target molecules based on real insight into the science will lead to faster downstream execution. The result is a higher throughput of successful drug-like compounds.

ADME screening services

discovery-biology

In vitro facilities at o2h provide ADME (absorption, distribution, metabolism, excretion) to provide faster and improved decision making points for our chemistry clients or standalone offering to support drug discovery programs.

We offer cost-efficient standardized and customized assays as per the client’s requirement for ADME parameters. Our ADME capabilities include:

ADME Assays

  • Physicochemical screening
    • Aqueous solubility (Thermodynamic & Kinetic)
    • Log P
    • Log D
  • Drug Metabolism
    • Microsomal Stability
    • Plasma Stability
    • Hepatocyte Stability
  • Protein Binding
    • Plasma Protein Binding
  • Permeability
    • PAMPA
  • Drug-Drug interaction
    • CYP inhibition assays (Fluorescent and LCMS/MS)

In vitro assays

in-vitro-assays

In vitro facilities at o2h have been developed to provide faster decision-making points for our chemistry clients.

We have doubled both our capacity as well as capability to include a range of pharmacology services to evaluate activity and/or potential liability of compounds. Our purpose-built labs include industry standard formats of fluorescence, luminescence and absorbance to help develop and optimise biochemical and/or cellular assays in a range of therapeutic areas.

o2h offers:

ADME Assays
Solubility (thermodynamic, kinetic), Log P/Log D studies, permeability (PAMPA), CYP inhibition (fluorescence, LCMS/MS based), microsomal stability, plasma stability, hepatocyte stability, plasma protein binding.

Target-based Assays
Enzymatic/kinase assays, binding assays, GPCR assays

Cell-based Assays
ELISA, proliferation/cytotoxicity, phosphorylation status, cytokine production assays using hPBMCs, signal transduction assays.

In vivo studies

in-vivo-studies-1

o2h has an in-depth expertise in performing standard bioavailability/tissue-distribution PK studies, acute/chronic toxicology studies as well as pathophysiologically relevant experimental models for multiple therapeutic indications.

The macroscopic observations can be corroborated with a range of different techniques including but not limited to histopathological analysis, estimation of haematological and/or biochemical parameters etc. Currently, the in-vivo experiments are performed only with rodents (e.g, mice, rats). Our in-vivo models are available on a fee-for-service basis as well as a part of an integrated biology project. We also have the capability to customise these models as per client requirement. In-vivo studies are done in conjunction with CROs with whom o2h has a preferred relationship for the past several years.

Examples of in vivo models include

  • Collagen-induced arthritis
  • Adjuvant-induced arthritis
  • DSS-induced colitis
  • TNBS-induced colitis
  • PMA-induced psoriasis/atopic dermatitis
  • IMQ-induced psoriasis/atopic dermatitis
  • Cytokine release assay
  • Single dose acute toxicity
  • Repeat dose toxicity study
  • Oral bioavailability study

Integrated drug discovery

integrated-drug-discovery-1

The ultimate metric to measure the success of Integrated Drug Discovery (IDD) project is the capacity to create intellectual property and value to our customers (e.g., identification of a lead compound demonstrating low nM activity under in vitro conditions and exhibiting statistically significant in vivo efficacy in a pathophysiologically-relevant disease model).

Successful IDD projects rely on efficient integration of various disciplines, medicinal chemistry experience, operational excellence and a pragmatic approach. o2h has taken a modular approach while establishing its IDD services to offer our clients maximum flexibility in their outsourcing decision.

Each of the varied module of the drug discovery process is available as a unique point of entry individually as a subset of services or as the traditional drug discovery pathway from hit identification through to lead generation and beyond. Our expertise includes – medicinal chemistry, hit identification, lead generation/optimisation, computational chemistry, in-vitro enzymatic and cell-based screening, DMPK and in-vivo models in multiple therapeutic areas. o2h doesn’t have an animal facility, the in-life phase for PK studies as well as in-vivo efficacy studies are done with CROs with whom we have a preferred relationship for the past several years.

o2h has strategic ties with several CROs in India and can help clients advance their projects to an IND application stage through chemical process scale-up and development (both GMP and non-GMP), bioanalytical studies, formulation approaches, safety-pharmacology and toxicology studies, clinical trial supplies, and medical writing. To know more about this, please write to us at info@o2h.com

Discovery News

02 Nov 2017

The quest to positively benefit the lives of patients in the world of drug discovery means finding novel therapeutics for unmet medical needs. The biotech and pharma companies have been increasingly resorting to external innovation to supplement their pipeline of ideas and turbocharge their research-based businesses with enterprising partners with complementary ideas, capabilities and services. It is therefore hardly surprising that the top medicinal chemists working in both large and small companies have multiple partners across different continents and time-zones. To deliver these iterative discovery projects often entails detailed co-ordination of inter-related activities and extensive multi-tasking. Project management is the hub that allows these complex matrices of networks to communicate and for the project to successfully advance. In today’s fast paced and technologically advanced digital world, providing the project manager the right tools to make informed decisions is key to successful delivery. o2h Discovery’s innovative app Chemistry in the Cloud TM builds upon the latest advances in secure cloud-based mobile technology and integrates project management of external drug discovery programs. The app enables communication between the various scientific stakeholders essential to successful project advancement leading to faster decision making. It negates the onerous tasks of weeding out critical information that is required to take a complex decision by extracting the information from large data intensive reports and databases. These crucial decision points are now just a ‘tap/swipe-of-the-finger’ in the Chemistry in the CloudTM app so that they can speedily execute tasks anytime, anywhere. The communication covering a gamut of research activities in relation to process of research now truly happens in 24/7 real-time. o2h announced a worldwide launch and first live demonstration of our revolutionary project management app – Chemistry in the Cloud TM on 10th September 2017 at the 19th RSC/SCI Cambridge medicinal chemistry conference to some of world’s top scientists. The app’s full suite of project management tools is available exclusively to live project collaborators and a lighter version is open for researchers looking for a quote for the synthesis of small molecules. https://www.linkedin.com/in/sunil-shah-4bb225/detail/recent-activity/shares/ Nilesh Dagia (nilesh@o2h.com) is the COO @ o2h Discovery

02 Nov 2017

Fast decision making, anytime, anywhere… For More Information - Press Release - Chemistry in the cloud

04 Oct 2017

IOTA has been funded to establish a Glioblastoma “drug bank” as part of their membership of the WINDOW Consortium. More information about the WINDOW project can be found at: http://www.sanger.ac.uk/news/view/brain-tumour-charity-grants-window-consortium-15-million-new-research-combination or IOTA website:http://www.iotapharma.com/news-details.aspx?id=20

@o2hventures

November 1st 2017 10:11:52

O2h Discovery: Chemistry in the Cloud™ - The World's First App To Project Manage Drug Discovery - https://t.co/LP0dpstmFI

@o2hventures

November 13th 2017 12:11:27

Read our COO Nilesh Dagia's thoughts on our App Launch - "CHEMISTRY IN THE CLOUD TM – The World’s First APP to Pro… https://t.co/kQpz3s74Om

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