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PROTACs are heterobifunctional small molecules that can also target proteins previously thought of as “undruggable”. In the last few years, o2h discovery has developed strong expertise in the synthesis and screening of complex PROTAC molecules, and related specialty chemistry and Protac Services. We provide comprehensive solutions for designing and synthesis of PROTAC building blocks, linkers, compound libraries, and related intermediates to support Targeted Protein Degradation.

PROTAC – o2h discovery’s biology expertise

🧬Our biology evaluation suite aims to help you estimate ternary complex formation and targeted protein degradation. Our team at o2h discovery has a customizable PROTAC toolbox™ kit of over 100 monomers, including various linkers, ligands and necessary controls to assist you with your PROTAC program.

 

Protac design

                      (Targeted Protein Degradation)

 

🔬 Our biologists team at o2h discovery can support you in addressing questions related to your PROTACs:

  • Is my target degraded?
  • Is my target ubiquitinated?
  • Do they form a ternary complex?
  • Are they soluble and cell permeable?
  • What is the binary affinity for POI and E3 ligase?
  • What is the phenotypic consequence of target degradation?

And many more…

 

                                              (PROTAC – Biology expertise at o2h discovery)

o2h discovery’s expertise in targeted protein degradation or PROTAC services

o2h discovery is a leading drug discovery organisation that provides custom synthesis services. We have the capabilities to support hit-to-lead and lead optimisation programs to create novel IP and bring small molecules to the IND filing stage.

In the last few years, we have developed strong expertise in the synthesis and screening of complex PROTAC molecules, and related specialty chemistry.

We provide comprehensive solutions for designing and synthesis of PROTAC building blocks, linkers, compound libraries, and related intermediates to support Targeted Protein Degradation.

o2h discovery offers a range of E3 ligase ligands from an “off the shelf toolbox” for the quick synthesis of PROTAC equipped with a variety of linkers for quick assembly of degrader analogues to accelerate your drug discovery and development process. 

Some of the molecule structures from our PROTAC toolbox™ – 

                          E3 Ligase (VHL generic scaffold)E3 Ligase (CRBN generic scaffold)

LinkersE3 Ligase + LinkersLinkers

 

To discover the full extent of the o2h PROTAC toolbox™ offers, please contact us at discovery@o2h.com.

We also developed a range of analytical methods and purification protocols for the isolation of high-quality complex PROTAC molecules and their accurate characterization. Several building blocks have been prepared at gm scale with reliable synthetic routes and purification methodologies.

Here is a recent testimonial from one of our clients to whom we provided PROTAC services and helped their team to deliver a range of personalized, cutting-edge Targeted Protein Degradation/PROTAC services:

 

          (Julian & Martin’s feedback about o2h discovery’s PROTAC services/targeted protein degradation)

If you want to Jump-start your PROTAC-based drug discovery program (targeted protein degradation), or would like to get a quote, write to us at discovery@o2h.com or visit PROTAC services.


If you want to give a chemistry boost to your early-stage biotech, please read about our o2h Kickstarter competition (UK)o2h Kickstarter competition 2.0 (Australia), and o2h Kickstarter competition 3.0 (Israel)

For more information, visit o2h.com or contact us at: https://o2h.com/contact/

 

 

Press Release – Curza and o2h discovery announce a multi-FTE chemistry collaboration against gram negative

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