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ImmuNext and o2h discovery collaborate to progress first-in-class drug discovery programs

o2h discovery is pleased to announce a productive multi FTE chemistry collaboration with ImmuNext to support their cutting-edge drug discovery program focused on developing new Antibody Drug Conjugates.

ImmuNext is developing immune-based therapies to treat patients with immune-related disorders, including inflammatory disease, autoimmune disorders, cancer, transplantation rejection, and infectious disease. They target critical immunomodulatory molecules that either promote or suppress immune responses to restore immune homeostasis and cure disease. 

o2h discovery is delighted to provide synthetic chemistry support to help ImmuNext create new linker-payloads to deliver their groundbreaking ADCs to patients. 

Jay Rothstein, CSO of ImmuNext said:o2h has helped us innovate novel payload-linker combinations for our INX200 program.Their expertise in medicinal chemistry along with their commitment to quality products and timely delivery was critical for our program’s success

Hemal Soni, Head of Chemistry of o2h discovery, said: “It has been a pleasure to support ImmuNext on their chemistry projects. The ImmuNext team has been an absolute pleasure to work with, and we are happy that by working together, we were able to provide an effective and productive outcome for some complex targets and help ImmuNext achieve their essential project milestones.”

About o2h discovery:

Founded in 2005, o2h discovery is a Contract Research Organisation which has an integrated drug discovery platform operating from our state-of-the-art research centre in India and The Mill SciTech Park, Cambridge, UK. We have the in-house capability to execute hit-lead-optimization programs leading into patent and IND filing from our state-of-the-art biotechnology incubator with expertise in discovery chemistry, biology, pharmacology, and the ongoing project management of pre-clinical development. 

o2h discovery has developed and launched its proprietary application Chemistry in the Cloud™ (CITC), the world’s first app to revolutionize the project management of external drug discovery programs. The app enables the communication between various scientific stakeholders essential to successful project advancement – leading to faster decision making. 

The DNA of o2h discovery is centered around the nurturing of its people, values, and culture. It reflects in the way we work with each other, as well as our collaborators and partners. 

For more information about o2h group, please visit www.o2h.com and to know more about our chemistry services, please see – https://o2h.com/discovery/chemistry/ 

About ImmuNext:

ImmuNext is a preclinical drug discovery company that develops novel immunotherapies for the treatment of autoimmune disease and cancer. ImmuNext has partnered immunotherapies with Janssen, Roche, Sanofi, Eli Lilly and Curis. Assets are currently in Phase 1 and Phase 2 trials.

For more information, please visit- www.immunext.com

Press Release – Curza and o2h discovery announce a multi-FTE chemistry collaboration against gram negative

o2h discovery expands synthetic chemistry collaboration with Sosei Heptares

Cambridge, UK, October 22 2019: o2h discovery is pleased to announce a significant expansion in its existing Synthetic Chemistry collaboration with Sosei Heptares, an international biopharmaceutical group focused on the design and development of new medicines originating from its proprietary GPCR-targeted StaR® technology and Structure-Based Drug Design platform capabilities.

o2h discovery supports biotechnology and pharmaceutical companies with drug discovery support from its research facility in Ahmedabad, India and is developing additional discovery biology capabilities from The Mill SciTech Park in Cambridge, UK which the o2h group recently acquired.

John Christopher, Director of Medicinal Chemistry at Sosei Heptares noted that: “Sosei Heptares has a long-standing collaboration with o2h discovery that has consistently delivered good value synthetic chemistry support across a number of our projects with flexible, fast delivery and excellent communication. We are delighted to be extending our interactions further though a significant expansion to the current team.”

Sunil Shah, CEO, o2h discovery, said “o2h discovery is delighted to deepen its collaboration with Sosei Heptares; a relationship that has spanned over a decade. We appreciate the confidence that the Sosei Heptares team place in o2h discovery and it is a privilege to provide to support the team with their discovery efforts”.

About o2h discovery:

o2h discovery has an integrated drug discovery platform operating from our state-of-the-art research center in Ahmedabad, India and The Mill SciTech Park, Cambridge, UK. We have the in-house capability to execute hit-lead-optimization programs leading into patent and IND filing from with expertise in discovery chemistry, biology, pharmacology and the on-going project management of pre-clinical development.

o2h discovery has developed and launched its proprietary application AI Chemistry in the CloudTM (AI-CITC) which is the world’s first app to revolutionize the project management of external drug discovery programs. The app enables communication between various scientific stakeholders essential to successful project advancement – leading to faster decision making.

The DNA of the o2h group is centered around the nurturing of its people, values and culture, it reflects in the way we work with each other, as well as our collaborators and partners. The vision of the o2h group is to seed new ideas in life-science, technology and social enterprise.

For more information, please visit www.o2h.com

Media Contact:

Ajit Singh

PR and Communications, o2h discovery

ajit@o2h.com

About Sosei Heptares:

Sosei Heptares is an international biopharmaceutical group focused on the design and development of new medicines originating from its proprietary GPCR-targeted StaR® technology and structure-based drug design platform capabilities. It is advancing a broad and deep pipeline of novel medicines across multiple therapeutic areas, including CNS, immuno-oncology, gastroenterology, inflammation and other rare/specialty indications. Its leading clinical programs include partnered candidates aimed at the symptomatic treatment of Alzheimer’s disease (with Allergan) and next-generation immuno-oncology approaches to treat cancer (with AstraZeneca).

Additional partners and collaborators include Takeda, Genentech, Novartis, Pfizer, Daiichi-Sankyo, PeptiDream, Kymab, MorphoSys. Sosei Heptares is headquartered in Tokyo, Japan with R&D facilities in Cambridge, UK.

“Sosei Heptares” is the corporate brand of Sosei Group Corporation, which is listed on the Tokyo Stock Exchange (ticker: 4565).

For more information, please visit https://www.soseiheptares.com/ or follow Sosei Heptares on LinkedIn: @soseiheptaresco | Twitter: @soseiheptaresco | YouTube: @soseiheptaresco

Media Contact for Sosei Heptares:

Mark Swallow/David Dible, Citigate Dewe Rogerson

+44 (0)20 7638 9571

SoseiHeptares@citigatedewerogerson.com

Press Release – Curza and o2h discovery announce a multi-FTE chemistry collaboration against gram negative