o2h discovery has an in-depth expertise in performing standard bioavailability/tissue-distribution PK studies, acute/chronic toxicology studies as well as pathophysiologically relevant experimental models for multiple therapeutic indications.
The macroscopic observations can be corroborated with a range of different techniques including but not limited to histopathological analysis, estimation of haematological and/or biochemical parameters etc. Currently, the in-vivo experiments are performed only with rodents (e.g, mice, rats). Our in-vivo models are available on a fee-for-service basis as well as a part of an integrated biology project. We also have the capability to customise these models as per client requirement. In-vivo studies are done in conjunction with CROs with whom o2h has a preferred relationship for the past several years.
Examples of in vivo models include
- Collagen-induced arthritis
- Adjuvant-induced arthritis
- DSS-induced colitis
- TNBS-induced colitis
- PMA-induced psoriasis/atopic dermatitis
- IMQ-induced psoriasis/atopic dermatitis
- Cytokine release assay
- Single dose acute toxicity
- Repeat dose toxicity study
- Oral bioavailability study