discovery-biology

ADME Screening Services

In vitro facilities at o2h provide ADME (absorption, distribution, metabolism, excretion) to provide faster and improved decision making points for our chemistry clients or standalone offering to support drug discovery programs.

We offer cost-efficient standardized and customized assays as per the client’s requirement for ADME parameters. Our ADME capabilities include:

ADME Assays

  • Physicochemical screening
    • - Aqueous solubility (Thermodynamic & Kinetic)
    • - Log P
    • - Log D

  • Drug Metabolism
    • - Microsomal Stability
    • - Plasma Stability
    • - Hepatocyte Stability
  • Protein Binding
    • - Plasma Protein Binding

  • Permeability
    • - PAMPA

  • Drug-Drug interaction
    • - CYP inhibition assays (Fluorescent and LCMS/MS)